SJFα
CAS No. 2254609-27-1
SJFα( —— )
Catalog No. M33558 CAS No. 2254609-27-1
SJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 473 | In Stock |
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| 5MG | 202 | In Stock |
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| 10MG | 376 | In Stock |
|
| 25MG | 803 | In Stock |
|
| 50MG | 1386 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSJFα
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NoteResearch use only, not for human use.
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Brief DescriptionSJFα (SJF alpha) is a PROTAC formed by an E3 ubiquitin ligase-conjugated protein hydrolysis regulator that degrades p38α and p38δ and can be used in cancer research.
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DescriptionSJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 μM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | PROTACs | p38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2254609-27-1
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Formula Weight1120.27
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Molecular FormulaC59H67F2N7O11S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (89.26 mM; Ultrasonic (<60°C)
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SMILESC(NC1=CC(F)=C(OC=2C3=C(C=C(OCCCCOCCCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C(OC)=C3)N=CC2)C=C1)(=O)C7(C(NC8=CC=C(F)C=C8)=O)CC7
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.?
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