CA-5f( —— )

Catalog No. M19958 CAS No. 1370032-19-1

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	93	In Stock
5MG	85	In Stock
10MG	140	In Stock
25MG	262	In Stock
50MG	415	In Stock
100MG	641	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

CA-5f
Note

Research use only, not for human use.
Brief Description

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
Description

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
In Vitro

Cell Viability Assay Cell Line:A549, HUVECs Concentration:20 μM Incubation Time:96 hours Result:Exhibited more cytotoxicity against A549 cells compared with normal HUVECs.Western Blot Analysis Cell Line:A549 cells and HUVECs Concentration:0-40 μM Incubation Time:6 hours Result:Elevated LC3B-II (a marker to monitor autophagy) and SQSTM1 protein levels in a concentration- and time-dependent manner.
In Vivo

Animal Model:Nude mice bearing A549 lung cancer cellsDosage:40 mg/kg Administration:Injected via caudal vein, every 2 days for up to 30 days Result:Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice.
Synonyms

——
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

——
Indication

——

Chemical Information

CAS Number

1370032-19-1
Formula Weight

388.46
Molecular Formula

C24H24N2O3
Purity

>98% (HPLC)
Solubility

DMSO: 70 mg/mL;Water: Insoluble
SMILES

COc1ccc(\C=C2/CN(C)C\C(=C/c3c[nH]c4ccccc34)C2=O)cc1OC
Chemical Name

(3E5E)-3-(34-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhang L et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406.

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