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CA-5f
CAS No. 1370032-19-1
CA-5f( —— )
Catalog No. M19958 CAS No. 1370032-19-1
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 262 | In Stock |
|
| 50MG | 415 | In Stock |
|
| 100MG | 641 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCA-5f
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NoteResearch use only, not for human use.
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Brief DescriptionCA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
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DescriptionCA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.
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In VitroCell Viability Assay Cell Line:A549, HUVECs Concentration:20 μM Incubation Time:96 hours Result:Exhibited more cytotoxicity against A549 cells compared with normal HUVECs.Western Blot Analysis Cell Line:A549 cells and HUVECs Concentration:0-40 μM Incubation Time:6 hours Result:Elevated LC3B-II (a marker to monitor autophagy) and SQSTM1 protein levels in a concentration- and time-dependent manner.
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In VivoAnimal Model:Nude mice bearing A549 lung cancer cellsDosage:40 mg/kg Administration:Injected via caudal vein, every 2 days for up to 30 days Result:Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice.
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number1370032-19-1
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Formula Weight388.46
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Molecular FormulaC24H24N2O3
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Purity>98% (HPLC)
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SolubilityDMSO: 70 mg/mL;Water: Insoluble
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SMILESCOc1ccc(\C=C2/CN(C)C\C(=C/c3c[nH]c4ccccc34)C2=O)cc1OC
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Chemical Name(3E5E)-3-(34-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhang L et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406.
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