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XRK3F2 B

CAS No. 2375193-43-2

XRK3F2 B( —— )

Catalog No. M33173 CAS No. 2375193-43-2

XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
5MG 75 In Stock
10MG 116 In Stock
25MG 224 In Stock
50MG 346 In Stock
100MG 520 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    XRK3F2 B
  • Note
    Research use only, not for human use.
  • Brief Description
    XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
  • Description
    XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/domain.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375193-43-2
  • Formula Weight
    435.89
  • Molecular Formula
    C23H24ClF2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 150 mg/mL (344.12 mM; Ultrasonic )H2O : 0.91 mg/mL (2.09 mM; Ultrasonic)
  • SMILES
    Cl.OCCNCc1ccc(OCc2ccc(F)cc2)c(OCc2ccc(F)cc2)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.?
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