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XRK3F2 B
CAS No. 2375193-43-2
XRK3F2 B( —— )
Catalog No. M33173 CAS No. 2375193-43-2
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 224 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 520 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameXRK3F2 B
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NoteResearch use only, not for human use.
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Brief DescriptionXRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
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DescriptionXRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/domain.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number2375193-43-2
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Formula Weight435.89
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Molecular FormulaC23H24ClF2NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 150 mg/mL (344.12 mM; Ultrasonic )H2O : 0.91 mg/mL (2.09 mM; Ultrasonic)
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SMILESCl.OCCNCc1ccc(OCc2ccc(F)cc2)c(OCc2ccc(F)cc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.?
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