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JHU395
CAS No. 2079938-92-2
JHU395( —— )
Catalog No. M32972 CAS No. 2079938-92-2
JHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 140 | In Stock |
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| 10MG | 242 | In Stock |
|
| 25MG | 464 | In Stock |
|
| 50MG | 709 | In Stock |
|
| 100MG | 1079 | In Stock |
|
| 200MG | 1451 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJHU395
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NoteResearch use only, not for human use.
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Brief DescriptionJHU395 is an orally-bioavailable prodrug of a lipophilic glutamine antagonist (GA), 6-diazo-5-oxo-L-norleucine (DON).
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DescriptionJHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2079938-92-2
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Formula Weight447.48
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Molecular FormulaC22H29N3O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (223.47 mM; Ultrasonic )
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SMILESC(OC(C(C)(C)C)=O)(OC(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)C1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Oxypalmatine
Oxypalmatine (8-Oxypalmatine) is a berberine-type alkaloid isolated from Phellodendron amurense that regulates breast cancer cell proliferation and apoptosis by inhibiting PI3K/AKT signaling and its efficacy in breast cancer-like organs.
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CSRM617 hydrochlorid...
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 μM in SPR assays, directly binding to the OC2-HOX domain.
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Bifenthrin
Bifenthrin is a synthetic pyrethroid insecticide.Bifenthrin induces cell death in bovine mammary epithelial cells through ROS generation, disruption of calcium homeostasis, and alteration of the MAPK signaling cascade.Bifenthrin induces apoptosis by inducing cell-cycle arrest.
