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AZD-4877
CAS No. 758722-49-5
AZD-4877( —— )
Catalog No. M37653 CAS No. 758722-49-5
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 334 | In Stock |
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| 5MG | 302 | In Stock |
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| 10MG | 451 | In Stock |
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| 25MG | 814 | In Stock |
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| 50MG | 1190 | In Stock |
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| 100MG | 1795 | In Stock |
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| 200MG | 2399 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD-4877
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NoteResearch use only, not for human use.
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Brief DescriptionAZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis.
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DescriptionAZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity.
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In VitroApoptosis Analysis Cell Line:UC1, UC3, UC6, UC12, UC15, RT4,JB,BV, T24 cell line Concentration:10 nM Incubation Time:24 or 48 hours Result:Induced apoptosis in human bladder cancer cells
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis | Kinesin
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Research Area——
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Indication——
Chemical Information
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CAS Number758722-49-5
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Formula Weight503.66
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Molecular FormulaC28H33N5O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N(C(=O)C1=CC=C(C)C=C1)CCCN)(C(C)C)C=2N(CC3=CC=CC=C3)C(=O)C4=C(N2)SN=C4C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Theoclitou ME, et.al. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. J Med Chem. 2011 Oct 13;54(19):6734-50. ?
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