Molibresib besylate( —— )

Catalog No. M32947 CAS No. 1895049-20-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Molibresib besylate
Note

Research use only, not for human use.
Brief Description

Molibresib besylate (GSK 525762C) is a selective and potent inhibitor of the bromodomain and extra-terminal (BET) family of proteins with potential anticancer activity for the study of refractory hematologic malignant diseases.
Description

Molibresib besylate (GSK 525762C; I-BET 762 besylate) is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Epigenetic Reader Domain | ROS
Research Area

——
Indication

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CAS Number

1895049-20-3
Formula Weight

582.07
Molecular Formula

C28H28ClN5O5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (42.95 mM; Ultrasonic )
SMILES

S(=O)(=O)(O)C1=CC=CC=C1.O(C)C=1C=C2C(N3C([C@H](CC(NCC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)=CC1
Chemical Name

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1. Nicodeme E, et al. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23;468(7327):1119-23.?

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