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UMB298
CAS No. 2266569-73-5
UMB298( —— )
Catalog No. M24031 CAS No. 2266569-73-5
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 101 | In Stock |
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| 5MG | 95 | In Stock |
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| 10MG | 153 | In Stock |
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| 25MG | 264 | In Stock |
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| 50MG | 363 | In Stock |
|
| 100MG | 496 | In Stock |
|
| 200MG | 643 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUMB298
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NoteResearch use only, not for human use.
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Brief DescriptionUMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
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DescriptionUMB298 is a potent and selective CBP/P300 bromodomain inhibitor. UMB298 inhibits BRD4 with IC50 of 5193nM.
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In VitroUMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth.UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression. Cell Viability Assay Cell Line:MOLM13 and MM cells Concentration:0.01~10 μM Incubation Time:50 days Result:Inhibited cells growth.Western Blot Analysis Cell Line:MOLM13 cells Concentration:1~10 μM Incubation Time:2 hours Result:Reduced the H3K27ac level similar to CBP30 and caused MYC depletion as a signature of CBP inhibition in acute myeloid leukemia.RT-PCR Cell Line:MOLM13 cells Concentration:3 μM Incubation Time:2 hours Result:Down-regulated MYC expression.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorBRD4
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Research Area——
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Indication——
Chemical Information
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CAS Number2266569-73-5
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Formula Weight479.01
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Molecular FormulaC27H31ClN4O2
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Purity>98% (HPLC)
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SolubilityDMSO:20mg/ml(41.75mM; need ultrasonic)
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SMILESCC1=C(C2=CC3=NC(CCC4=CC=C(OC)C(Cl)=C4)=C(NC5CCCCC5)N3C=C2)C(C)=NO1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Development of Dimethylisoxazole-Attached Imidazo[1,2- a]pyridines as Potent and Selective CBP/P300 Inhibitors[J]. Journal of medicinal chemistry, 64(9):5787-5801.
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