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Calcium channel-modulator-1

CAS No. 136941-70-3

Calcium channel-modulator-1( —— )

Catalog No. M32746 CAS No. 136941-70-3

Calcium channel-modulator-1, a calcium channel-modulator (IC50: 0.8 μM), specializes in blocking aortic constriction.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Calcium channel-modulator-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Calcium channel-modulator-1, a calcium channel-modulator (IC50: 0.8 μM), specializes in blocking aortic constriction.
  • Description
    Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.
  • In Vitro
    ——
  • In Vivo
    Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    136941-70-3
  • Formula Weight
    579.45
  • Molecular Formula
    C26H24Cl2N2O7S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(OCCCN1S(=O)(=O)C=2C(C1=O)=CC=CC2)(=O)C=3C(C(C(OC)=O)=C(C)NC3C)C4=C(Cl)C(Cl)=CC=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sunkel CE, et al. Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators. J Med Chem. 1992 Jun 26;35(13):2407-14.?
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