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Hexa-D-arginine TFA

CAS No. 958204-56-3

Hexa-D-arginine TFA( Furin Inhibitor II TFA )

Catalog No. M29859 CAS No. 958204-56-3

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Hexa-D-arginine TFA
  • Note
    Research use only, not for human use.
  • Brief Description
    Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
  • Description
    Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively). (In Vitro):Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.(In Vivo):Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
  • In Vitro
    Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
  • In Vivo
    Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
  • Synonyms
    Furin Inhibitor II TFA
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    958204-56-3
  • Formula Weight
    1068.17
  • Molecular Formula
    C38H76F3N25O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:Arg-Arg-Arg-Arg-Arg-Arg-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
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