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Home - Products - GPCR/G Protein - Antibacterial - AFN-1252

AFN-1252

CAS No. 620175-39-5

AFN-1252( API-1252 | Debio-1452 )

Catalog No. M15347 CAS No. 620175-39-5

A potent inhibitor of bacterial enoyl-ACP reductase FabI.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 92 In Stock
2MG 56 In Stock
5MG 92 In Stock
10MG 147 In Stock
25MG 275 In Stock
50MG 412 In Stock
100MG 607 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AFN-1252
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of bacterial enoyl-ACP reductase FabI.
  • Description
    A potent inhibitor of bacterial enoyl-ACP reductase FabI; demonstrates MICs of 0.015 and 0.008 ug/ml for S. aureus ATCC 29213 and S. aureus ATCC 33592 (MRSA), respectively; demonstrates a Staphylococcus-specific spectrum of activity.Bacterial Infection Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female 5- to 6-week-old CD-1 mice (18 to 22 g) with S. aureus Smith bacterial inoculumDosage:0.03, 0.1, 0.3, 1, 3 mg/kg Administration:Oral gavage; single dose Result:Was efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg. The calculated ED50s (95% confidence limits) were 0.15 (0.11 to 0.21) mg/kg.
  • Synonyms
    API-1252 | Debio-1452
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    enoyl-acylcarrierproteinreductase(FabI)
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    620175-39-5
  • Formula Weight
    375.4204
  • Molecular Formula
    C22H21N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 5.8 mg/mL (Need ultrasonic)
  • SMILES
    O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C3=CC(CC4)=C(N=C3)NC4=O
  • Chemical Name
    2-Propenamide, N-methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-, (2E)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Karlowsky JA, et al. Antimicrob Agents Chemother. 2007 Apr;51(4):1580-1. 2. Karlowsky JA, et al. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8. 3. Parsons JB, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15378-83.
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