Proanthocyanidins(b)

Research use only, not for human use.

Proanthocyanidins is a natural produceused as antioxidant and anti-cancers agent.

Proanthocyanidins is a natural produceused as antioxidant and anti-cancers agent.

Proanthocyanidin are present in plants as complex mixtures of polymers. Predominant food sources are red wine, tea, chocolate and fruits like grapes, apples, pears, and cranberries.?The most interesting antibacterial activity of Proanthocyanidin is related to their presence in cranberries (Vaccinium macrocarpon Ait.). A number of clinical trials have demonstrated the effectiveness of cranberry consumption in preventing urinary tract infections (UTIs). Although UTIs can be caused by many microorganisms, more than 85% are caused by Escherichia coli. The presence of P-fimbriae on E. coli, which are proteinaceous fibers on the bacterial cell wall, has been clearly established as a virulence factor, since they are responsible by producing adhesions for adherence to uroepithelial cells. Recently, it is demonstrated that cranberry Proanthocyanidin might inhibit P-fimbriated E. coli from adhering to uroepithelial cells. The antiadhesion activity of cranberry juice appears to be related to the presence of Proanthocyanidin with at least one A-type linkage.

The effects of cacao liquor Proanthocyanidin on 2- amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced mutagenesis in vivo carcinogenesis in female Sprague-Dawley rats are investigated. In the Ames assay, Proanthocyanidin shows strong antimutagenic effects when assayed in the presence of S-9 mixture. They also inhibit significantly rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis.

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GPCR/G Protein

Antibacterial

Bacterial

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20347-71-1

594.52

C30H26O13

>98% (HPLC)

H2O:5 mg/mL (8.41 mM; ultrasonic and adjust pH to 11 with Na2CO3)

C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC4(C(C(C5=C(C=C(C=C5O4)O)O)O)O)C6=CC(=C(C=C6)O)O

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(-20℃)

With Ice Pack

≥ 2 years