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HBX 41108

CAS No. 924296-39-9

HBX 41108( HBX-41108 )

Catalog No. M27424 CAS No. 924296-39-9

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

HBX 41108
Note

Research use only, not for human use.
Brief Description

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
Description

HBx 41108 is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBx 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
In Vitro

——
In Vivo

——
Synonyms

HBX-41108
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

Bax|Bcl-2|Caspase-3
Research Area

——
Indication

——

Chemical Information

CAS Number

924296-39-9
Formula Weight

266.64
Molecular Formula

C13H3ClN4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (937.59 mM)
SMILES

Clc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Zhou D, et al. Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum. Phytochemistry. 2019;164:172-183.

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