STD1T( USP2a inhibitor STD1T )

Catalog No. M16439 CAS No. 893075-58-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

STD1T
Note

Research use only, not for human use.
Brief Description

STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays.
Description

STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays, displays no activity against USP7 at 10 uM.
In Vitro

STD1T inhibits USP2a enzymatic activity in a concentration dependent manner. STD1T shows selective inhibition of USP2a vs. USP7 at the concentrations of 10 μM and 2000 μM, respectively.
In Vivo

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Synonyms

USP2a inhibitor STD1T
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

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Indication

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CAS Number

893075-58-6
Formula Weight

417.498
Molecular Formula

C19H19N3O4S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (149.70 mM)
SMILES

O=C(C1=C(NC(COCC2=NOC(C3=CC=CS3)=C2)=O)SC4=C1CCCC4)N
Chemical Name

2-(2-((5-(thiophen-2-yl)isoxazol-3-yl)methoxy)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

1. Tomala MD, et al. Eur J Med Chem. 2018 Apr 25;150:261-267.

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