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MK8745
CAS No. 885325-71-3
MK8745( —— )
Catalog No. M19230 CAS No. 885325-71-3
MK-8745 is a potent and selective Aurora A inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 31 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 82 | In Stock |
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| 50MG | 133 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMK8745
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NoteResearch use only, not for human use.
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Brief DescriptionMK-8745 is a potent and selective Aurora A inhibitor.
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DescriptionMK-8745 is a potent and selective Aurora A inhibitor.
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In VitroMK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorAurora A| Aurora B
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number885325-71-3
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Formula Weight431.91
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Molecular FormulaC20H19ClFN5OS
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 34 mg/mL; 78.72 mM
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SMILESC1CN(CCN1Cc1nc(ccc1)Nc1nccs1)C(=O)c1c(c(ccc1)Cl)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chowdhury A, et al. Leuk Lymphoma. 2012, 53(3), 462-471.
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