USP25 and 28 inhibitor AZ-2( USP25/28 inhibitor AZ2 )

Catalog No. M13456 CAS No. 2165322-95-0

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Datasheet

HNMR

HPLC

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Product Name

USP25 and 28 inhibitor AZ-2
Note

Research use only, not for human use.
Brief Description

USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
Description

USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
In Vitro

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In Vivo

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Synonyms

USP25/28 inhibitor AZ2
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

CAS Number

2165322-95-0
Formula Weight

420.226
Molecular Formula

C17H17BrF3NO3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C1=CC(=CC(=C1)OC(F)(F)F)COC2=C(C=C(C=C2)Br)CNCCO
Chemical Name

2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol

1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.

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