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USP25 and 28 inhibitor AZ-2
CAS No. 2165322-95-0
USP25 and 28 inhibitor AZ-2( USP25/28 inhibitor AZ2 )
Catalog No. M13456 CAS No. 2165322-95-0
USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameUSP25 and 28 inhibitor AZ-2
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NoteResearch use only, not for human use.
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Brief DescriptionUSP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
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DescriptionUSP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines.
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In Vitro——
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In Vivo——
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SynonymsUSP25/28 inhibitor AZ2
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number2165322-95-0
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Formula Weight420.226
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Molecular FormulaC17H17BrF3NO3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC(=CC(=C1)OC(F)(F)F)COC2=C(C=C(C=C2)Br)CNCCO
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Chemical Name2-((5-bromo-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethan-1-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wrigley JD, et al. ACS Chem Biol. 2017 Nov 28. doi: 10.1021/acschembio.7b00334.
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