Dimethindene maleate( SU 6518 | SU-6518 | UNII-6LL60J9E0O | Dimethindene maleate )

Catalog No. M27412 CAS No. 3614-69-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dimethindene maleate
Note

Research use only, not for human use.
Brief Description

Dimethindene maleate is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis.
Description

Dimethindene maleate is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis.
In Vitro

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM.Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM.
In Vivo

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice. Animal Model:C57BL/6 mice with wound healing Dosage:0.25 mg Administration:Intraperitoneal injection; 0.25 mg once Result:Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.
Synonyms

SU 6518 | SU-6518 | UNII-6LL60J9E0O | Dimethindene maleate
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

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Research Area

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Indication

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1.K D Brunnemann, et al. N-Nitrosomorpholine and Other Volatile N-nitrosamines in Snuff Tobacco. Carcinogenesis. 1982;3(6):693-6.

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