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MRT-83
CAS No. 1263131-92-5
MRT-83( —— )
Catalog No. M26307 CAS No. 1263131-92-5
MRT-83 is a potent Smo antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 55 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 183 | In Stock |
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| 50MG | 310 | In Stock |
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| 100MG | 437 | In Stock |
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| 200MG | 616 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMRT-83
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NoteResearch use only, not for human use.
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Brief DescriptionMRT-83 is a potent Smo antagonist.
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DescriptionMRT-83 is a potent Smo antagonist.(In Vitro):MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays.(In Vivo): MRT-83 can't up-regulation of Ptc transcription in the SVZ of these animals in agreement with complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects.
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In VitroMRT-83 displays full antagonist properties with an IC50 (~3 nM) for inhibiting ShhN (3 nM)-induced proliferation of rat GCPs. MRT-83 also blocks SAG (0.01 μM)-induced proliferation of GCPs (IC50 ~6 nM). MRT-83 blocks BC binding to HEK-hSmo cells in a dose-dependent manner with an IC50 of 4.6 nM. MRT-83 abrogates BC binding to cells expressing mouse Smo with an IC50 of 14 nM, which is in good correlation with its IC50 in the Shh-light2 and alkaline phosphatase assays.
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In VivoAnimals treated with ShhN in the presence of MRT-83 are as healthy as those of the other groups but up-regulation of Ptc transcription in the SVZ of these animals is no longer observed in agreement with a complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects. MRT-83 but not MRT-36 antagonizes the up-regulation of Ptc transcription induced by ShhN in vivo in the SVZ of the LV.
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetSmoothened (Smo)
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1263131-92-5
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Formula Weight538.604
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Molecular FormulaC31H30N4O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (464.17 mM)
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SMILESCOc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhang, H., Sun, J., Xin, X., et al. Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system. J. Colloid. Interface Sci. 467, 43-50 (2016).
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