Cart
sales@molnova.com
GSK256073
CAS No. 862892-90-8
GSK256073( —— )
Catalog No. M24859 CAS No. 862892-90-8
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
|
| 2MG | 93 | In Stock |
|
| 5MG | 155 | In Stock |
|
| 10MG | 250 | In Stock |
|
| 25MG | 440 | In Stock |
|
| 50MG | 634 | In Stock |
|
| 100MG | 901 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGSK256073
-
NoteResearch use only, not for human use.
-
Brief DescriptionGSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.
-
DescriptionGSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.
-
In Vitro——
-
In VivoAnimal Model:SD ratDosage:1, 30 and 100 mg/kg Administration:Oral adminstration Result:Inhibited NEFA expression as a dose-dependent manner. Animal Model:Guinea pigs Dosage:10 mg/kg Administration: Intravenous?injection Result:Had the antilipolytic and flushing effects as a HCA2 agonist.
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetGPR
-
RecptorGPR109A|HCA2 (hydroxy-carboxylic acid receptor 2)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number862892-90-8
-
Formula Weight256.69
-
Molecular FormulaC10H13ClN4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:16.67 mg/mL?(64.94 mM;?Need ultrasonic)
-
SMILESCCCCCN1C2=C(C(=O)NC1=O)NC(=N2)Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab.?2013 Nov;15(11):1013-21.
molnova catalog
related products
-
SC75741
SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.
-
GPR35 agonist 2
GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respectively.
-
BTB09089
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
