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AH 7614
CAS No. 6326-06-3
AH 7614( —— )
Catalog No. M24637 CAS No. 6326-06-3
AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
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| 10MG | 75 | In Stock |
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| 25MG | 165 | In Stock |
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| 50MG | 295 | In Stock |
|
| 100MG | 401 | In Stock |
|
| 200MG | 522 | In Stock |
|
| 500MG | 678 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAH 7614
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NoteResearch use only, not for human use.
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Brief DescriptionAH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
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DescriptionAH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
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In VitroAH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.?AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70).AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
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In VivoAH7614 (50μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.AH7614 (50μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGPR120
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Research Area——
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Indication——
Chemical Information
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CAS Number6326-06-3
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Formula Weight351.42
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Molecular FormulaC20H17NO3S
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Purity>98% (HPLC)
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SolubilityDMSO:35.1 mg/mL(100 mM);Ethanol:Insoluble;Water:Insoluble
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SMILESO=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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WAY-298630
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and conjunctivitis.
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hGPR91 antagonist 1
hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM).GPR91, a 7TM G-Protein-Coupled Receptor, has been recently deorphanized with succinic acid as its endogenous ligand.?Current literature indicates that GPR91 plays role in various pathophysiology including renal hypertension, autoimmune disease and retinal angiogenesis.?
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BigLEN (rat)
Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.
