Cart
sales@molnova.com
TUG-499
CAS No. 1206629-08-4
TUG-499( —— )
Catalog No. M35364 CAS No. 1206629-08-4
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 2MG | 29 | In Stock |
|
| 5MG | 46 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 111 | In Stock |
|
| 50MG | 145 | In Stock |
|
| 100MG | 191 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTUG-499
-
NoteResearch use only, not for human use.
-
Brief DescriptionTUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).
-
DescriptionTUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes. TUG-499 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
In VitroTUG-499 (compound 7) demonstrates high chemical stability, no inhibition of selected CYP enzymes or P-glycoprotein, and excellent Caco-2 permeability. TUG-499 has potent activity on recombinant human FFA1 receptors and on the rat insulinoma cell line INS-1E.
-
In Vivo——
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetGPR
-
RecptorGPR | PPAR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1206629-08-4
-
Formula Weight320.17
-
Molecular FormulaC16H11Cl2NO2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC(#CC1=CC=C(CCC(O)=O)C=C1)C=2C=C(Cl)N=C(Cl)C2
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Elisabeth Christiansen, et al. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. J Med Chem. 2011 Oct 13;54(19):6691-703.?
molnova catalog
related products
-
Grp94 Inhibitor-1
Grp94 Inhibitor-1 is a potent selective Grp94 inhibitor (IC50 : 2 nM).?
-
Kisspeptin-10, human...
Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis?inhibitor.?Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54.?Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development.
-
GPR81 agonist 1
GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81, inhibiting lipolysis of differentiated 3T3-L1 adipocytes, improving insulin sensitivity and glycaemic control in mouse models of insulin resistance and diabetes, and can be used in the study of diabetes and obesity.
