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Home - Products - Cell Cycle/DNA Damage - GPR - TUG-499

TUG-499

CAS No. 1206629-08-4

TUG-499( —— )

Catalog No. M35364 CAS No. 1206629-08-4

TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 48 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 65 In Stock
25MG 111 In Stock
50MG 145 In Stock
100MG 191 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TUG-499
  • Note
    Research use only, not for human use.
  • Brief Description
    TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).
  • Description
    TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) (Free Fatty Acid Receptor) agonist with a pEC50 of 7.39. TUG-499 exhibits >100-fold selectivity over the related receptors FFA2, FFA3, and the nuclear receptor PPARγ and other diverse receptors, ion channels, and transporters. TUG-499 can be used for the research of type 2 diabetes. TUG-499 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    TUG-499 (compound 7) demonstrates high chemical stability, no inhibition of selected CYP enzymes or P-glycoprotein, and excellent Caco-2 permeability. TUG-499 has potent activity on recombinant human FFA1 receptors and on the rat insulinoma cell line INS-1E.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR | PPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1206629-08-4
  • Formula Weight
    320.17
  • Molecular Formula
    C16H11Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(#CC1=CC=C(CCC(O)=O)C=C1)C=2C=C(Cl)N=C(Cl)C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Elisabeth Christiansen, et al. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties. J Med Chem. 2011 Oct 13;54(19):6691-703.?
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