MS21570

Research use only, not for human use.

MS21570 as a GPR171 antagonist based on its ability to blockwith an IC50 of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.

MS21570 as a GPR171 antagonist based on its ability to blockwith an IC50 of 220 Nmthat reduces anxiety-like behavior and fear conditioning in mice.

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MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist.

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Cell Cycle/DNA Damage

GPR

GPR171

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65373-29-7

237.34

C10H11N3S2

>98% (HPLC)

DMSO:125 mg/mL (526.67 mM)

CNc1nnc(SCc2ccccc2)s1

5-(benzylthio)-N-methyl-134-thiadiazol-2-amine

(-20℃)

With Ice Pack

≥ 2 years