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Latanoprost acid

CAS No. 41639-83-2

Latanoprost acid( —— )

Catalog No. M33406 CAS No. 41639-83-2

Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 155 In Stock
5MG 141 In Stock
10MG 226 In Stock
25MG 453 In Stock
50MG 658 In Stock
100MG 904 In Stock
200MG 1200 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Latanoprost acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway.
  • Description
    Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
  • In Vitro
    Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1. Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK. Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation. Western Blot Analysis Cell Line:Bone marrow-derived macrophages cells (BMMs) Concentration:10 μM, 20 μM Incubation Time:24 hours Result:Reduced he protein expressions of c-fos and NFATc1.
  • In Vivo
    Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg. Animal Model:8-week-old C57BL/6J mice Dosage:20 mg/kg Administration: Intraperitoneally injected; once a day for 7 days Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41639-83-2
  • Formula Weight
    390.51
  • Molecular Formula
    C23H34O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (256.08 mM; Ultrasonic )
  • SMILES
    O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weinreb RN, et al. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S53-64.?
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