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Compound W
CAS No. 173550-33-9
Compound W( —— )
Catalog No. M23782 CAS No. 173550-33-9
The compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 39 | In Stock |
|
| 50MG | 61 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCompound W
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NoteResearch use only, not for human use.
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Brief DescriptionThe compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
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DescriptionThe compound is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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Recptorγ secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number173550-33-9
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Formula Weight396.31
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Molecular FormulaC19H12N2O8
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Purity>98% (HPLC)
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SolubilityDMSO:<39.63mg/mL;1.1eq. NaOH:<19.81mg/mL
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SMILES[O-][N+](c(cc1)ccc1Oc1cc(C(O)=O)cc(Oc(cc2)ccc2[N+]([O-])=O)c1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Jagged-1 188-204
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-αB activation.
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Demcizumab
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
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Enoticumab
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
