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LY900009
CAS No. 209984-68-9
LY900009( —— )
Catalog No. M23950 CAS No. 209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 89 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 115 | In Stock |
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| 25MG | 207 | In Stock |
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| 50MG | 300 | In Stock |
|
| 100MG | 434 | In Stock |
|
| 200MG | 609 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY900009
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NoteResearch use only, not for human use.
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Brief DescriptionLY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
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DescriptionLY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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Recptorγ secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number209984-68-9
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Formula Weight409.49
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Molecular FormulaC23H27N3O4
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C(C)C)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Jagged-1 188-204
This peptide is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolayers to JAG-1 with elevated calcium concentration produces stratification with loricrin expression and NF-αB activation.
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Enoticumab
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits the growth of cancer cells.Enoticumab binds human Dll4 and disrupts Notch-mediated signaling.
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Demcizumab
Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody and a potent Notch pathway inhibitor, demonstrating efficacy in various cancer models both as a monotherapy and in conjunction with chemotherapy agents.
