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RBPJ Inhibitor-1
CAS No. 2682114-39-0
RBPJ Inhibitor-1( —— )
Catalog No. M34771 CAS No. 2682114-39-0
RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 76 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 227 | In Stock |
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| 50MG | 384 | In Stock |
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| 100MG | 554 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRBPJ Inhibitor-1
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NoteResearch use only, not for human use.
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Brief DescriptionRBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.
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DescriptionRBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
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In VitroCell Viability Assay Cell Line:AD-293 cells were transfected with RBPJ-VP16myc.Concentration:2 μM.Incubation Time:17 hours.Result:Inhibited Hes1-Luciferase activity with an IC50 of 0.18 μM and Emax of 82%.Inhibited NOTCH3 ICD with similar potency and efcacy (0.19 μM and Emax=88%).Cell Proliferation Assay Cell Line:T-cell acute lymphoblastic leukemia (T-ALL) patients (Jurkat and KOPT-K1) and in the mantle cell lymphoma (MCL) line REC-1.Concentration:0.1-10 μM.Incubation Time:96 h. Result:Inhibited NOTCH-dependent tumor cell proliferation.
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGamma-secretase
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RecptorGamma-secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number2682114-39-0
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Formula Weight311.31
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Molecular FormulaC17H14FN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (803.06 mM; Ultrasonic )
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SMILESO(C1=C(C(N)=O)C=CC(=C1)C=2N(C)N=CC2)C3=C(F)C=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.?
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