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RBPJ Inhibitor-1

CAS No. 2682114-39-0

RBPJ Inhibitor-1( —— )

Catalog No. M34771 CAS No. 2682114-39-0

RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
2MG 46 In Stock
5MG 76 In Stock
10MG 132 In Stock
25MG 227 In Stock
50MG 384 In Stock
100MG 554 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    RBPJ Inhibitor-1
  • Note
    Research use only, not for human use.
  • Brief Description
    RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cell proliferation.
  • Description
    RBPJ Inhibitor-1 (RIN1), the first RBPJ inhibitor, blocks the functional interaction of RBPJ with SHARP. RBPJ Inhibitor-1 (RIN1) inhibits NOTCH-dependent tumor cell proliferation.
  • In Vitro
    Cell Viability Assay Cell Line:AD-293 cells were transfected with RBPJ-VP16myc.Concentration:2 μM.Incubation Time:17 hours.Result:Inhibited Hes1-Luciferase activity with an IC50 of 0.18 μM and Emax of 82%.Inhibited NOTCH3 ICD with similar potency and efcacy (0.19 μM and Emax=88%).Cell Proliferation Assay Cell Line:T-cell acute lymphoblastic leukemia (T-ALL) patients (Jurkat and KOPT-K1) and in the mantle cell lymphoma (MCL) line REC-1.Concentration:0.1-10 μM.Incubation Time:96 h. Result:Inhibited NOTCH-dependent tumor cell proliferation.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    Gamma-secretase
  • Recptor
    Gamma-secretase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2682114-39-0
  • Formula Weight
    311.31
  • Molecular Formula
    C17H14FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (803.06 mM; Ultrasonic )
  • SMILES
    O(C1=C(C(N)=O)C=CC(=C1)C=2N(C)N=CC2)C3=C(F)C=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cecilia Hurtado, et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci Rep. 2019 Jul 25;9(1):10811.?
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