Gossypolone( —— )

Catalog No. M34612 CAS No. 4547-72-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Gossypolone
Note

Research use only, not for human use.
Brief Description

Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.
Description

Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a Ki of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer.
In Vitro

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In Vivo

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Synonyms

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Pathway

Neuroscience
Target

Gamma-secretase
Recptor

Gamma-secretase | Wnt/beta-catenin
Research Area

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Indication

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CAS Number

4547-72-2
Formula Weight

546.52
Molecular Formula

C30H26O10
Purity

>98% (HPLC)
Solubility

——
SMILES

C(=O)C1=C2C(=C(C(C)C)C(O)=C1O)C(=O)C(C)=C(C2=O)C=3C(=O)C=4C(C(=O)C3C)=C(C(C)C)C(O)=C(O)C4C=O
Chemical Name

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1. Lan L, et al. Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins. BMC Cancer. 2018 Aug 10;18(1):809.?

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