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BPAM344

CAS No. 1204572-55-3

BPAM344( —— )

Catalog No. M23375 CAS No. 1204572-55-3

BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BPAM344
  • Note
    Research use only, not for human use.
  • Brief Description
    BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
  • Description
    BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.
  • In Vitro
    BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    Kainate receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1204572-55-3
  • Formula Weight
    242.27
  • Molecular Formula
    C10H11FN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (1031.91 mM)
  • SMILES
    FC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Larsen A P , Fievre S , Frydenvang K , et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors[J]. Molecular Pharmacology, 2017:mol.116.107599.
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