PF-04958242( PF04958242 )

Catalog No. M11068 CAS No. 1258963-59-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-04958242
Note

Research use only, not for human use.
Brief Description

PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM.
Description

PF-04958242 is a novel potent, selctive, and orally-active AMPA receptor (AMPAR) positive allosteric modulator (PAM) with Ki of 170 nM, EC50 of 370 nM; is under development for the treatment of cognitive symptoms in schizophrenia.Schizophrenia Phase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

PF04958242
Pathway

Membrane Transporter/Ion Channel
Target

iGluR
Recptor

iGluR
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

1258963-59-5
Formula Weight

392.49
Molecular Formula

C18H20N2O4S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (254.78 mM)
SMILES

CC(C)S(=O)(=O)NC1COCC1OC2=CC=C(C=C2)C3=CC=C(S3)C#N
Chemical Name

N-((3S,4S)-4-(4-(5-cyano-2-thienyl)phenoxy)tetrahydro-3-furanyl)-2-propanesulfonamide

1. Shaffer CL, et al. J Med Chem. 2015 May 28;58(10):4291-308. 2. Ranganathan M, et al. Mol Psychiatry. 2017 Feb 28. doi: 10.1038/mp.2017.6.

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