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Selurampanel

CAS No. 912574-69-7

Selurampanel( BGG 492 )

Catalog No. M16551 CAS No. 912574-69-7

Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Selurampanel
  • Note
    Research use only, not for human use.
  • Brief Description
    Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
  • Description
    Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM; displays >100-fold selectivity over NMDA and kainate receptors; demonstrates excellent oral potency against MES-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy.Epilepsy Discontinued.
  • In Vitro
    ——
  • In Vivo
    Selurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min?kg.
  • Synonyms
    BGG 492
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Epilepsy

Chemical Information

  • CAS Number
    912574-69-7
  • Formula Weight
    377.418
  • Molecular Formula
    C16H19N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CS(=O)(NN1C(NC2=C(C=C(C3=CC=NN3C)C(C(C)C)=C2)C1=O)=O)=O
  • Chemical Name
    N-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methanesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Orain D, et al. ChemMedChem. 2017 Feb 3;12(3):197-201. 2. Kasteleijn-Nolst Trenité D, et al. Epilepsia. 2015 Jun;56(6):924-32. 3. Faught E. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13.
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