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Selurampanel
CAS No. 912574-69-7
Selurampanel( BGG 492 )
Catalog No. M16551 CAS No. 912574-69-7
Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 267 | In Stock |
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| 5MG | 256 | In Stock |
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| 10MG | 369 | In Stock |
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| 25MG | 568 | In Stock |
|
| 50MG | 793 | In Stock |
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| 100MG | 1097 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSelurampanel
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NoteResearch use only, not for human use.
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Brief DescriptionSelurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
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DescriptionSelurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM; displays >100-fold selectivity over NMDA and kainate receptors; demonstrates excellent oral potency against MES-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy.Epilepsy Discontinued.
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In Vitro——
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In VivoSelurampanel (Compound 1S) potently and dose-dependently antagonizes maximal electroshock seizure (MES)-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.In a study with a 3 mg/kg i.v. dose, a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min?kg.
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SynonymsBGG 492
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PathwayMembrane Transporter/Ion Channel
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TargetiGluR
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RecptoriGluR
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Research AreaNeurological Disease
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IndicationEpilepsy
Chemical Information
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CAS Number912574-69-7
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Formula Weight377.418
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Molecular FormulaC16H19N5O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESCS(=O)(NN1C(NC2=C(C=C(C3=CC=NN3C)C(C(C)C)=C2)C1=O)=O)=O
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Chemical NameN-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methanesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Orain D, et al. ChemMedChem. 2017 Feb 3;12(3):197-201.
2. Kasteleijn-Nolst Trenité D, et al. Epilepsia. 2015 Jun;56(6):924-32.
3. Faught E. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13.
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