Cart
sales@molnova.com
Procyanidin B1
CAS No. 20315-25-7
Procyanidin B1( —— )
Catalog No. M22664 CAS No. 20315-25-7
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 217 | In Stock |
|
| 5MG | 169 | In Stock |
|
| 10MG | 275 | In Stock |
|
| 25MG | 465 | In Stock |
|
| 50MG | 638 | In Stock |
|
| 100MG | 900 | In Stock |
|
| 200MG | 1190 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameProcyanidin B1
-
NoteResearch use only, not for human use.
-
Brief DescriptionProcyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells.
-
DescriptionProcyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells. Procyanidin B1 (50-100 μM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at concentrations of 30, 50, and 100 μM and caspase-9 at concentrations of 10, 30, 50, and 100 μM. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα.
-
In VitroProcyanidin B1 is a polyphenolic flavonoid isolated from fruits and fruit juices, binds to TLR4/MD-2 complex, and has anti-inflammatory activity. Procyanidin B1 causes cellular toxicity at concentrations >100 μg/mL. Procyanidin B1 (100 μg/mL) inhibits LPS-induced TNF-α production, and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK and NF-κB protein in THP1 cells. Procyanidin B1 (50-100 μM) protects against Aβ oligomer-induced neuronal death. Procyanidin B1 potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at concentrations of 30, 50, and 100 μM and caspase-9 at concentrations of 10, 30, 50, and 100 μM. Procyanidin B1 (10, 20, 30 μM) significantly and dose-dependently induces expression of ACO and CPT1, with no obvious effect on mRNA expression of PPARα.
-
In Vivo——
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetTLR
-
RecptorTLR4/MD-2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number20315-25-7
-
Formula Weight578.52
-
Molecular FormulaC30H24O12
-
Purity>98% (HPLC)
-
SolubilityDMSO:23 mg/mL (39.76 mM; Need ultrasonic)
-
SMILESO[C@H]1Cc2c(O)cc(O)c([C@@H]3[C@@H](O)[C@H](Oc4cc(O)cc(O)c34)c3ccc(O)c(O)c3)c2O[C@@H]1c1ccc(O)c(O)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Xing J, et al. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling. Mol Cell Biochem. 2015 Sep;407(1-2):89-95.
molnova catalog
related products
-
Pam3CSK4
Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
-
Afimetoran
Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases.
-
Isatoribine
Isatoribine (ANA245;7-Thia-8-oxoguanosine;Immunosine) is a nucleoside analogue, selective agonist of TLR7 with significant antiviral effect and mmunoenhancing activity.
