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Pam3CSK4
CAS No. 112208-00-1
Pam3CSK4( Pam3Cys-Ser-(Lys)4 )
Catalog No. M29767 CAS No. 112208-00-1
Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePam3CSK4
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NoteResearch use only, not for human use.
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Brief DescriptionPam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.
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DescriptionPam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.(In Vitro):Pam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides. Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus.(In Vivo):Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice.
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In VitroPam3CSK4 is a TLR1/2 heterodimer recognises triacylated lipopeptides.Pam3CSK4 (1 μg/mL) enhances the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils to Methicillin-resistant Staphylococcus aureus.
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In VivoPam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice. Animal Model:Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) miceDosage:5 mg/kg Administration:Intraperitoneally (i.p.); once a day for 9 days Result:After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12.
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SynonymsPam3Cys-Ser-(Lys)4
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PathwayImmunology/Inflammation
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TargetTLR
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number112208-00-1
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Formula Weight1510.23
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Molecular FormulaC81H156N10O13S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameSequence:{Pam3Cys}-Ser-Lys-Lys-Lys-Lys
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50.
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