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SSD114 hydrochloride

CAS No. 2319790-02-6

SSD114 hydrochloride( —— )

Catalog No. M22387 CAS No. 2319790-02-6

SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 39 In Stock
2MG 29 In Stock
5MG 46 In Stock
10MG 69 In Stock
25MG 113 In Stock
50MG 177 In Stock
100MG 300 In Stock
200MG 433 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SSD114 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
  • Description
    SSD114 hydrochloride is a GABAB receptor positive allosteric modulator.
  • In Vitro
    In the presence of 10 μM GABA, SSD114 hydrochloride at 25 μM significantly increases (to approximately 170% above basal levels) the [35S]GTPγS stimulation induced by GABA alone. SSD114 hydrochloride, added at 15 and 30 μM, induces a leftward shift of the GABA concentration-response curve with a slight concomitant increase of maximal GABA stimulation at the highest concentration. In the presence of both 15 and 30 μM SSD114 hydrochloride, the EC50 for GABA decreases by 2 and 2.5 fold, respectively, while the maximal stimulation (Emax) is potentiated only at the concentration of 30 μM, reaching 161±5.09% over the basal value .
  • In Vivo
    The onset of loss of righting reflex (LORR) is reduced by pretreatment with SSD114 hydrochloride [F(5,30)=4.55, P<0.005]. Post hoc analysis indicates that the onset of LORR is significantly lower in mouse groups pretreated with doses of SSD114 hydrochloride equal to or higher than 10 mg/kg than in vehicle-treated mice. The duration of LORR is increased by pretreatment with SSD114 hydrochloride [F(5,30)=4.81, P<0.005]. Post hoc analysis indicates that the duration of LORR is significantly longer in mouse groups pretreated with 10 and 100 mg/kg SSD114 hydrochloride than in vehicle-treated mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GABA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2319790-02-6
  • Formula Weight
    387.83
  • Molecular Formula
    C18H21ClF3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:130 mg/mL (335.20 mM; Need ultrasonic)
  • SMILES
    Cl.COc1cc(nc(NC2CCCCC2)n1)-c1ccc(cc1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Porcu A, et al. In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB positive allosteric modulator. Eur J Pharmacol. 2016 Nov 15;791:115-123.
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