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PAC1R antagonist 1
CAS No. 2305204-24-2
PAC1R antagonist 1( —— )
Catalog No. M37140 CAS No. 2305204-24-2
PAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasms and immune-related disorders.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePAC1R antagonist 1
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NoteResearch use only, not for human use.
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Brief DescriptionPAC1R antagonist 1 is an orally active PAC1 receptor antagonist that inhibits abnormal pain induced by pituitary adenylate cyclase-activating polypeptide (PACAP) and nerve damage, and may be used in the study of neoplasms and immune-related disorders.
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DescriptionPAC1R antagonist 1 (compound 3d) is a potent and orally active antagonist of PAC1 receptor. PAC1R antagonist 1 can inhibit pituitary adenylate cyclase-activating polypeptide (PACAP)- and nerve injury-induced allodynia.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPACAP
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Research Area——
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Indication——
Chemical Information
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CAS Number2305204-24-2
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Formula Weight372.81
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Molecular FormulaC17H17ClN6O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (89.40 mM; ultrasonic and warming and heat to 160°C )
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SMILESO=C(NCCC1=CN=CN1)C2CC(=O)N(C3=NNC=4C(Cl)=CC=CC34)C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takasaki I, et, al. Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain. Eur J Med Chem. 2020 Jan 15;186:111902. ?
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