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INH14
CAS No. 200134-22-1
INH14( —— )
Catalog No. M20088 CAS No. 200134-22-1
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 145 | In Stock |
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| 100MG | 230 | In Stock |
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| 200MG | 341 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameINH14
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NoteResearch use only, not for human use.
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Brief DescriptionINH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
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DescriptionINH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
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In Vitro——
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In VivoINH14 (5 μg/g, i.p. for 2 hours) reduces lipopeptide-induced inflammation in mice. Animal Model:8-week old, male, pathogen-free C57BL/6J mice Dosage:5 μg/g, one hour before Pam2CSK4 injection Administration:I.P. for 2 hours Result:Decreased TNFα production in mice.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIKKα| IKKβ
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Research Area——
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Indication——
Chemical Information
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CAS Number200134-22-1
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Formula Weight240.3
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Molecular FormulaC15H16N2O
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Purity>98% (HPLC)
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SolubilityDMSO: 100 mg/mL (416.14 mM)
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SMILESCCc1ccc(NC(=O)Nc2ccccc2)cc1
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Chemical NameN-(4-Ethylphenyl)-N'-phenylurea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Drexel M et al. INH14 a Small-Molecule Urea Derivative Inhibits the IKKα/β-Dependent TLR Inflammatory Response. Chembiochem. 2019 Mar 1;20(5):710-717.
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