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IκB kinase (IKK)
The IκBs form a small family of related proteins with a core consisting of six or more ankyrin repeats, an N-terminal regulatory domain and a C-terminal domain that contains a PEST motif. There is strong biochemical and genetic evidence that the IKK complex, which consists of two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ, is the master regulator of NF-κB-mediated innate immune and inflammatory responses. The best-studied and major IκB protein is IκBα.IκB kinase activity is essential for activation of members of the nuclear factor-kB (NF-κB) family of transcription factors, which play a fundamental role in lymphocyte immunoregulation. Increased NF-κB activity as a result of constitutive IKK-mediated phosphorylation of IκBα has been observed in the development of atherosclerosis, asthma, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis.
Immunology/Inflammation
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IκB kinase (IKK)
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HOIPIN-8 sodium
catalog no : M35672
cas no: 2519537-70-1
HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1.
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IKK2-IN-4
catalog no : M34854
cas no: 354811-10-2
IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
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ACHP
catalog no : M33778
cas no: 406208-42-2
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β.
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GSK319347A
catalog no : M33384
cas no: 862812-98-4
GSK319347A is a selective and potent dual inhibitor of TBK1 and IKKε with potential anti-tumor activity and inhibition of IKK2 activity, which can be used in the study of bladder cancer and lung adenocarcinoma.
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HPN-01
catalog no : M32960
cas no: 928655-63-4
HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.