WS-3( WS3 | WS 3 )

Catalog No. M11759 CAS No. 1421227-52-2

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HNMR

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Product Name

WS-3
Note

Research use only, not for human use.
Brief Description

A small molecule that can induce proliferation of β cells with EC50 of 74 nM.
Description

A small molecule that can induce proliferation of β cells with EC50 of 74 nM; modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway; can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.
In Vitro

WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
In Vivo

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Synonyms

WS3 | WS 3
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

ErbB3-BindingProtein-1(EBP1)|IκBkinase
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1421227-52-2
Formula Weight

569.5781
Molecular Formula

C28H30F3N7O3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 43 mg/mL
SMILES

CN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
Chemical Name

Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-

1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. 2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.

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