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WS-3
CAS No. 1421227-52-2
WS-3( WS3 | WS 3 )
Catalog No. M11759 CAS No. 1421227-52-2
A small molecule that can induce proliferation of β cells with EC50 of 74 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 5MG | 33 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 184 | In Stock |
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| 100MG | 305 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameWS-3
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule that can induce proliferation of β cells with EC50 of 74 nM.
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DescriptionA small molecule that can induce proliferation of β cells with EC50 of 74 nM; modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway; can reversibly proliferates primary RPE cells isolated from fetal and adult human donors.
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In VitroWS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.
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In Vivo——
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SynonymsWS3 | WS 3
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorErbB3-BindingProtein-1(EBP1)|IκBkinase
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1421227-52-2
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Formula Weight569.5781
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Molecular FormulaC28H30F3N7O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 43 mg/mL
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SMILESCN1CCN(CC2=CC=C(NC(NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
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Chemical NameCyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Swoboda JG, et al. ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
2. Shen W, et al. J Am Chem Soc. 2013 Feb 6; 135(5):1669-72.
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