Nervonic acid

Research use only, not for human use.

Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin. It consists of choline sphingosine phosphoric acid and fatty acid.

Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin. It consists of choline sphingosine phosphoric acid and fatty acid. Nervonic acid may enhance the brain functions and prevent demyelination (Chemical Land21). Research shows that there is negative relationship between nervonic acid and obesity-related risk factors. Demyelination in adrenoleukodystrophy (ALD) is associated with an accumulation of very long chain saturated fatty acids stemming from a genetic defect in the peroxisomal beta oxidation system responsible for the chain shortening of these fatty acids. Sphingolipids from post mortem ALD brain have decreased levels of nervonic acid 24:1(n-9) and increased levels of stearic acid 18:0.

Cell Viability Assay Cell Line:PC-12 Concentration:0.001, 0.01, 0.1, 1. 10 μM Incubation Time:48 h Result:Increased cell viability pretreated with a very low concentration.Western Blot Analysis Cell Line:RAW264.7 Concentration:12.5, 25, 50 μM Incubation Time:24 h Result:Decreased the expression of TLR4, JNK, P38 and NF-κB.

Animal Model:MPTP-induced PD mice modelDosage:20, 40, 60 mg/kg Administration:i.g.Result:Reversed behavioral deficits inhibited the α-synuclein expression and regulated oxidative stress response.Animal Model:DSS-induced colitis mice modelDosage:5, 50, 100mg/kg Administration:i.g.Result:Improved the symptoms of diarrhea, weight loss and fecal occidental blood.Reduced the levels of COX-2 and iNOS.

cis-15-Tetracosenoic acid | Selacholeic acid

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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506-37-6

366.62

C24H46O2

>98% (HPLC)

DMSO:10 mM;Water:1mg/mL

CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years