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Anlotinib Dihydrochloride

CAS No. 1360460-82-7

Anlotinib Dihydrochloride( Anlotinib (AL3818) dihydrochloride | AL3818 dihydrochloride )

Catalog No. M19393 CAS No. 1360460-82-7

Anlotinib also known as AL3818 is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Anlotinib Dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Anlotinib also known as AL3818 is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities.
  • Description
    Anlotinib also known as AL3818 is a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. Upon administration anlotininib targets multiple RTKs including vascular endothelial growth factor receptor type 2 (VEGFR2) and type 3 (VEGFR3). This agent may both inhibit angiogenesis and halt tumor cell growth.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Anlotinib (AL3818) dihydrochloride | AL3818 dihydrochloride
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    VEGFR2| VEGFR3|c-Kit
  • Research Area
    Cancer
  • Indication
    Non-small cell lung Cancer

Chemical Information

  • CAS Number
    1360460-82-7
  • Formula Weight
    480.36
  • Molecular Formula
    C23H24Cl2FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:87 mg/mL(181.1 mM)
  • SMILES
    Cc1cc2c([nH]1)ccc(c2F)Oc1c2cc(c(cc2ncc1)OCC1(CC1)N)OC.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yongkun Sun et al. Safety pharmacokinetics and antitumor properties of anlotinib an oral multi-target tyrosine kinase inhibitor in patients with advanced refractory solid tumors. Journal of Hematology & Oncology20169:105
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