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VEGFR
Blood vessels are required for the growth and dissemination of a solid tumor. There are numerous growth factors involved in tumor angiogenesis, but foremost among them is the family of vascular endothelial growth factors (VEGFs). The VEGF family includes VEGFA, VEGFB, VEGFC, VEGFD, and placenta growth factor (PGF). These ligands bind with different affinities to three endothelial receptor tyrosine kinases (RTKs), such as VEGFR1, VEGFR2, and VEGFR3, as well as co-receptors, including neuropilins and heparan sulfate proteoglycans. VEGFA has been studied more than other family members and is a critical regulator of angiogenesis. VEGFA is usually referred to simply as VEGF. Vascular endothelial growth factor promotes tumor angiogenesis through stimulating the proliferation and survival of endothelial cells and also by increasing the permeability of vessels and recruiting vascular precursor cells from the bone marrow. VEGF has some direct effects on cancer cells or cancer stem cells. VEGF might promote cancer cell proliferation through the activation of VEGFR1 signaling. VEGFA/neuropilin-1 pathway conferred cancer stemness via the activation of the Wnt/β-catenin axis in breast cancer cells, also promotes tumor-initiating cell self-renewal through VEGFR2/STAT3 signaling.
References
1.Yang J,et al. Front Immunol. 2018;9:978.
References
1.Yang J,et al. Front Immunol. 2018;9:978.
Angiogenesis
VEGFR
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TIE-2/VEGFR-2 kinase-IN-5
catalog no : M37252
cas no: 1014407-83-0
TIE-2/VEGFR-2 kinase-IN-5 (TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor) is a potent agent with anti-angiogenic activity, commonly used in biomedical research focused on angiogenesis.
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Icrucumab
catalog no : M36749
cas no: 1024603-92-6
Icrucumab ( IMC-18F1) is a humanized IgG1 monoclonal antibody targeting vascular endothelial growth factor receptor-1.
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Parsatuzumab
catalog no : M36701
cas no: 1312797-14-0
Parsatuzumab (RG 7414) is a humanized monoclonal antibody targeting EGFL7, which is also used as an immunomodulator.
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GW297361
catalog no : M36628
cas no: 388627-21-2
GW297361 is a potent inhibitor of the cell cycle protein-dependent kinase Cdk1 and also inhibits the Pho85 signaling pathway.The IC50s of GW297361 on yeast Cdk1 and Pho85 were 20 nM and 400 nM, respectively.
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VEGFR-3-IN-1
catalog no : M36479
cas no: 2756668-73-0
VEGFR-3-IN-1 is a novel, potent, and selective VEGFR3 inhibitor with an IC50 of 110.4 nM.