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Ginsenoside Rb3

CAS No. 68406-26-8

Ginsenoside Rb3( Ginsenoside C, Ginsenoside-Rb3, HY-N0041, HYN0041 )

Catalog No. M18996 CAS No. 68406-26-8

Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ginsenoside Rb3
  • Note
    Research use only, not for human use.
  • Brief Description
    Ginsenoside Rb3 is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA.
  • Description
    Ginsenoside Rb3 is found in species of Panax. It inhibits contractions in aortic rings, decreases blood glucose levels, and improves oral glucose tolerance, improves immobility time in the forced swim tail suspension, and learned helplessness tests, and inhibits oxidative damage.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ginsenoside C, Ginsenoside-Rb3, HY-N0041, HYN0041
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    68406-26-8
  • Formula Weight
    1079.2
  • Molecular Formula
    C53H90O22
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (92.66 mM)
  • SMILES
    O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)CO1)[C@]([C@H]1CC[C@]2([C@@]3(CC[C@H]4C([C@H](CC[C@@]4([C@H]3C[C@H]([C@H]12)O)C)O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@H](O2)CO)[C@@H](O)[C@H](O)[C@H](O1)CO)(C)C)C)C)(CCC=C(C)C)C
  • Chemical Name
    (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-dihydroxy-2-(((3S,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ma L, et al. Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-κB pathway: a mouse cardiomyocyte model. PLoS One. 2014 Aug 1;9(8):e103628.
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