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GSK269962A
CAS No. 850664-21-0
GSK269962A( GSK 269962 )
Catalog No. M17614 CAS No. 850664-21-0
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 5MG | 78 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 226 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK269962A
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NoteResearch use only, not for human use.
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Brief DescriptionGSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
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DescriptionGSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley rats (350-400g)Dosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 12 hours Result:Induced a dose-dependent reduction in blood pressure.
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SynonymsGSK 269962
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PathwayAngiogenesis
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TargetVEGFR
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RecptorMSK1| ROCK1| ROCK2| RSK1
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number850664-21-0
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Formula Weight570.61
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Molecular FormulaC29H30N8O5
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 30 mg/mL; 52.58 mM
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SMILESCCn1c2cc(ncc2nc1c1nonc1N)Oc1cccc(c1)NC(=O)c1ccc(cc1)OCCN1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.
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