GSK269962A( GSK 269962 )

Catalog No. M17614 CAS No. 850664-21-0

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	103	In Stock
5MG	78	In Stock
10MG	117	In Stock
25MG	226	In Stock
50MG	368	In Stock
100MG	538	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

GSK269962A
Note

Research use only, not for human use.
Brief Description

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
Description

GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
In Vitro

——
In Vivo

Animal Model:Male Sprague-Dawley rats (350-400g)Dosage:0.3, 1, and 3 mg/kg Administration:Oral gavage; 12 hours Result:Induced a dose-dependent reduction in blood pressure.
Synonyms

GSK 269962
Pathway

Angiogenesis
Target

VEGFR
Recptor

MSK1| ROCK1| ROCK2| RSK1
Research Area

Cardiovascular Disease
Indication

——

Chemical Information

CAS Number

850664-21-0
Formula Weight

570.61
Molecular Formula

C29H30N8O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 30 mg/mL; 52.58 mM
SMILES

CCn1c2cc(ncc2nc1c1nonc1N)Oc1cccc(c1)NC(=O)c1ccc(cc1)OCCN1CCOCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks