Tyrphostin AG1433

Research use only, not for human use.

Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).

Tyrphostin AG1433 is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).(In Vitro):In glioblastoma cells, administration of Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) induces moderate cytotoxicity .(In Vivo):Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new vessels under the pellets .

Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells.Cell Viability Assay Cell Line:GB8B cells Concentration:0.1 μM, 1 μM, 5 μM, 10 μM, 20 μM, 30 μM, 50 μM, 60 μM, 100 μM Incubation Time:72 hours Result:Induced significant cell death in GB8B cells in a concentration-dependent manner.

Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.

SU1433 | AG1433

Angiogenesis

VEGFR

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168835-90-3

266.29

C16H14N2O2

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (234.71 mM)

OC1=CC=C(C2=NC3=CC(C)=C(C)C=C3N=C2)C=C1O

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(-20℃)

With Ice Pack

≥ 2 years