Tulathromycin A( Tulathromycin | Draxxin | Tulathromycin A | CP-472,295 )

Catalog No. M17437 CAS No. 217500-96-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Tulathromycin A
Note

Research use only, not for human use.
Brief Description

Tulathromycin A is a macrolide antibiotic.
Description

Tulathromycin A, also known as Tulathromycin and CP-472295, is a macrolide antibiotic used to treat bovine respiratory disease (BRD) in cattle and swine respiratory disease in pigs.
In Vitro

Tulathromycin A (Tulathromycin) represents the first member of a novel subclass of macrolides, known as triamilides.Tulathromycin A (0.02 to 2.0 mg/mL) induces time- and concentration-dependent apoptosis in neutrophils, which enhances their subsequent clearance by macrophages.
In Vivo

In the lungs of both A pleuropneumoniae- and zymosan-challenged pigs, Tulathromycin A (2.5 mg/kg, IM) promotes leukocyte apoptosis and efferocytosis and inhibites proinflammatory leukotriene B4 production, with a concurrent reduction in leukocyte necrosis relative to that of control pigs. Tulathromycin A also attenuates the degree of lung damage and lesion progression in A pleuropneumoniae-inoculated pigs.
Synonyms

Tulathromycin | Draxxin | Tulathromycin A | CP-472,295
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Antibacterial
Research Area

Infection
Indication

——

CAS Number

217500-96-4
Formula Weight

806.09
Molecular Formula

C41H79N3O12
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 45 mg/mL; 55.83 mM
SMILES

CCCNC[C@]1(O)[C@H](C)O[C@H](C[C@@]1(C)OC)O[C@H]1[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
Chemical Name

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one

1.Villarino N, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4078-4086.

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