Fexofenadine hydrochloride b

Research use only, not for human use.

Fexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.

Fexofenadine is a second generation antihistamine that is used for the treatment of allergic rhinitis angioedema and chronic urticaria.

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.Western Blot Analysis Cell Line:Nasal Fibroblasts Concentration:100 μM Incubation Time:1 hourResult:Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis. Animal Model:C57BL/6 mice infected with Trichinella spiralis Dosage:5, 10 and 20 mg/kg Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

Terfenidine carboxylate hydrochloride | MDL-16455 hydrochloride | Fexofenadine HCl | MDL 16455A | Telfast | Allegra

GPCR/G Protein

Histamine Receptor

Histamine H1 receptor

Metabolic Disease

Allergic rhinitis; Urticaria

153439-40-8

538.13

C32H39NO4·HCl

>98% (HPLC)

DMSO:26.9 mg/mL (50 mM)

Cl.CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1

——

(-20℃)

With Ice Pack

≥ 2 years