Fexofenadine hydrochloride

Research use only, not for human use.

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms.

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.(In Vitro):Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.(In Vivo):Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.

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GPCR/G Protein

Histamine Receptor

H1 receptor

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138452-21-8

538.12

C32H4OCINO4

>98% (HPLC)

DMSO: 10 mM

[H+].[Cl-].CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years