pocapavir

Research use only, not for human use.

Pocapavir is an investigational enterovirus (EV) capsid inhibitor.

Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections.(In Vitro):Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication.

Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication.

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SCH-48973 | SCH48973 | SCH 48973 | V074

Autophagy

Autophagy

Antiviral

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146949-21-5

423.72

C21H17Cl3O3

>98% (HPLC)

DMSO : 100 mg/mL. 236.00 mM; H2O : < 0.1 mg/mL

COc1ccc(OCc2ccc(COc3c(Cl)cccc3Cl)cc2)c(Cl)c1

1,3-dichloro-2-((4-((2-chloro-4-methoxyphenoxy)methyl)benzyl)oxy)benzene

(-20℃)

With Ice Pack

≥ 2 years