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MPP+ iodide
CAS No. 36913-39-0
MPP+ iodide( —— )
Catalog No. M24329 CAS No. 36913-39-0
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 30 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 60 | In Stock |
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| 50MG | 91 | In Stock |
|
| 100MG | 152 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 369 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMPP+ iodide
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NoteResearch use only, not for human use.
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Brief DescriptionMPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra.
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DescriptionMPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
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In VitroCell Viability Assay Cell Line:SH-SY5Y cells Concentration:1, 2, 3 mM Incubation Time:24 hours Result:SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number36913-39-0
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Formula Weight297.13
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Molecular FormulaC12H12IN
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL (210.34 mM; Need ultrasonic);Water:100 mg/mL (336.54 mM; Need ultrasonic)
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SMILESC[n+](cc1)ccc1-c1ccccc1.[I-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.
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