NVP-TNKS656( NVPTNKS656 | TNKS656 | TNKS656 )

Catalog No. M17287 CAS No. 1419949-20-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

NVP-TNKS656
Note

Research use only, not for human use.
Brief Description

NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
Description

NVP-TNKS656, also known as TNKS656, is a potent and orally active Tankyrase Inhibitor. With an enthalpy-driven thermodynamic signature of binding, highly favorable physicochemical properties, and high lipophilic efficiency, NVP-TNKS656 is well suited for further in vivo validation studies. Bioactivity of TNKS656: TNKS2 IC50 = 6nM, LiPE = 7.0, HEK298 STF IC50 = 3.5nM, Cmax/ Cellular IC50 = 23,000.
In Vitro

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In Vivo

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Synonyms

NVPTNKS656 | TNKS656 | TNKS656
Pathway

Neuroscience
Target

Gamma-secretase
Recptor

TNKS2
Research Area

Cancer
Indication

——

CAS Number

1419949-20-4
Formula Weight

494.58
Molecular Formula

C27H34N4O5
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 40 mg/mL. 80.88 mM
SMILES

COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc(=O)c3c(CCOC3)[nH]2)CC1
Chemical Name

N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide

1. Shultz MD, et al. J Med Chem. 2013, 56(16), 6495-6511.

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