Cart
sales@molnova.com
BI-1408
CAS No. 2231075-94-6
BI-1408( —— )
Catalog No. M32808 CAS No. 2231075-94-6
BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 331 | In Stock |
|
| 10MG | 451 | In Stock |
|
| 25MG | 634 | In Stock |
|
| 50MG | 768 | In Stock |
|
| 100MG | 977 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameBI-1408
-
NoteResearch use only, not for human use.
-
Brief DescriptionBI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).
-
DescriptionBI-1408 is a potent γ secretase modulator with an IC50 of 0.04 μM for Aβ42.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayNeuroscience
-
TargetGamma-secretase
-
RecptorGamma-secretase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2231075-94-6
-
Formula Weight390.46
-
Molecular FormulaC22H23FN6
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN(C=1N=C2C(=CC=CN2N1)C3=C(C)C=C(F)C=C3)[C@H]4CC5=C(CC4)N(CC)N=C5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26(12):3227-3241.?
molnova catalog
related products
-
Legumain inhibitor 1
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.
-
Aβ-IN-1
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharmacokinetic profile.
-
γ-Secretase modulato...
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that inhibits the production of amyloid β-peptide Aβ42 and can be used to study Alzheimer's disease and tumors.
