XEN-907( XEN907 | XEN 907 )

Catalog No. M16553 CAS No. 912656-34-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

XEN-907
Note

Research use only, not for human use.
Brief Description

A potent, selective NaV1.7 blocker with IC50 of 3 nM.
Description

A potent, selective NaV1.7 blocker with IC50 of 3 nM; shows no significant activity at 10 uM against a broad panel of 63 receptors and transporters; has no cytotoxic and favourable hepatocyte metabolic stability for both human and dog,Pain Preclinical.
In Vitro

XEN907 is not cytotoxic in HepG2 cells (% viable after 16 h: >99%).XEN907 shows moderate hepatocyte stability (% remaining after 2 h: rat 21%; human 34%; dog 46%) across species.
In Vivo

XEN907 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (13 %), Cmax (35 ng/mL), and AUClast (143 h?ng/mL) in rats.XEN907 (3 mg/kg; i.v.) exhibits terminal elimination half-life (2.6 h), high plasma clearance (9.4 L/h/kg), and large volumes of distribution (35.0 L/kg) in rats.
Synonyms

XEN907 | XEN 907
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

Neurological Disease
Indication

Pain

CAS Number

912656-34-9
Formula Weight

351.3958
Molecular Formula

C21H21NO4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(C12COC3=C1C=C(OCO4)C4=C3)N(CCCCC)C5=C2C=CC=C5
Chemical Name

Spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3'-[3H]indol]-2'(1'H)-one, 1'-pentyl-

1. Chowdhury S, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3676-81.

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